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- date : 2018-12-28 21:27|hit : 2738
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- Article] Clinical benefits of aspirin desensitization in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease are not related to urinary eicosanoid release and are accompanied with decreased urine creatinine
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DocNo of ILP : 11786
Document Type : Article
Document Title : Clinical benefits of aspirin desensitization in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease are not related to urinary eicosanoid release and are accompanied with decreased urine creatinine
Authors : Makowska, JS; Olszewska-Ziaber, A; Bienkiewicz, B; Lewandowska-Polak, A; Kurowski, M; Wozniakowski, B; Rotkiewicz, A; Kowalski, ML
Author Full Name : Makowska, Joanna S.; Olszewska-Ziaber, Agnieszka; Bienkiewicz, Barbara; Lewandowska-Polak, Anna; Kurowski, Marcin; Wozniakowski, Bartlomiej; Rotkiewicz, Arkadiusz; Kowalski, Marek L.
Author Keywords :
Keywords Plus? : ENDOSCOPIC SINUS SURGERY; LEUKOTRIENE E-4 EXCRETION; LONG-TERM TREATMENT; QUALITY-OF-LIFE; ASTHMATIC-PATIENTS; INTOLERANT ASTHMA; SENSITIVE RHINOSINUSITIS; NATURAL-HISTORY; STANDARD GAMBLE; INDUCED SPUTUM
Abstract : Background: Treatment with acetylsalicylic acid (ASA) after desensitization may be a therapeutic option in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). The mechanisms that lead to improvement in rhinosinusitis and asthma symptoms remain unknown. Aim: To attribute the documented clinical effects of ASA treatment of chronic rhinosinusitis and/or asthma to the release of eicosanoid metabolites in urine. Methods: Fourteen patients with NERD were successfully desensitized, and, eventually, eight patients were treated with 650 mg of ASA daily for 3 months. In addition to clinical assessments, nuclear magnetic resonance imaging and smell test were performed before and after treatment with ASA. Venous blood and urine were collected before desensitization and after 1 and 3 months of treatment. The levels of urinary leukotrienes (LT) (cysteinyl LT and LTE4) and tetranor PGDM (metabolite of prostaglandin D2) were measured by enzyme-linked immunosorbent assay. Results: Treatment with ASA after desensitization alleviated symptoms of rhinosinusitis, improved nasal patency (mean, 50% decrease in peak nasal inspiratory flow) and sense of smell (fourfold increase in smell test score) in as early as 4 weeks. Clinical improvements were not accompanied by any change in sinonasal mucosa thickness as assessed with nuclear magnetic resonance. Urinary cysteinyl LTs, LTE4, and prostaglandin D2 metabolite remained relatively stable during ASA treatment and did not correlate with clinical improvements. Desensitization was associated with a progressive decrease of urinary creatinine. Conclusion: Clinical improvement in rhinosinusitis and/or asthma after ASA desensitization was not related to concentrations of urinary eicosanoid metabolites. A decrease of urinary creatinine requires further study to determine the renal safety of long-term treatment with ASA after desensitization.
Web of Science Categories : Allergy
Year Published : 2016
Publisher : OCEAN SIDE PUBLICATIONS INC
Publisher City : PROVIDENCE
Language : English
Cited Reference Count : 51
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